21 years ago, a little boy named Kuroo Hazama is fatally injured in a horrible bomb accident. He survives through countless hours of critical surgery and endures a long, tortuous rehabilitation. Suddenly, one day, the boy’s father who abandoned him and his mother twenty-one years ago shows up on the door of his son, now Black Jack the medical genius. But soon after his unexpected reunion with his father, Black Jack’s house is bombed by someone. Eventually, Black Jack’s shocking truth behind his birth reveals. It is a big conspiracy that shakes up the world!